Mexico history starts with the time when the region was known as Mesoamerica.

Mesoamerican civilizations included the Olmec, Maya, and Toltec. In 1325 the Aztec, a Nahuatlan tribe, settled in the Valley of Mexico, becoming the preeminent power in central and southern Mexico by the 15th century. In 1519, Cortés conquered the Aztecs, and Spain gained control of the region, which became known as New Spain. The post Columbian Mexico history starts from this era, the concept of a Mexican pharmacy still a long way ahead.

With the appointment of the first Spanish viceroy in 1535, the basic form of colonial government was instituted for the first time in Mexico history. Life in colonial Mexico history was characterized by the exploitation of the Native Americans and the existence of rigid social classes, including Native Americans, mestizos, black slaves, freed blacks, and white Mexicans. But by the beginning of the 19th century resentment against Spanish rule and the inefficient government of New Spain, combined with the occupation of Spain by French emperor Napoleon I, resulted in the Mexican war for independence.

In 1821 Agustín de Iturbide, a criollo general, and a revolutionary leader Vicente Guerrero met and signed the Plan of Iguala, combining their forces to bring about independence from Spain.This plan of Iguala has got graet importance in Mexican history. The injured were treated at a Mexican pharmacy, a rare offering at that time. Had the Mexican Pharmacy not been there, casualties would have risen sharply. This forced the last viceroy of New Spain to accept the Treaty of Córdoba in 1821, marking the day of independence for the first time in Mexico history.

Mexico